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Who Are They?

To the Lumine and the Laminae, they are a group of guides and guardians.There are twelve of them, six Sirians and six Lyrians. The Lumine identify with a Lyrian while every Laminae identifies with a Sirian.

Sirians - Place of Origin

Sirius is the brightest star in the night sky

often called the Dog Star in the constellation Canis Major (the Great Dog)

It is actually Two Stars: Sirius A and Sirius B that orbit each other. In Lamina this represents two different canine species: the Wolf People and the Fox People.

In Lamina it is the “Waiting Seed” named Nucloendo 

The Laminae are a race that emerges later in the life of Lamina

Sirians - By Name

Baileyi - Timber wolf

Sinatu - Iberian wolf

Simmen - Ethiopian Wolf

Vul - Red fox

Zerda - Fennec fox

Uroc - Gray fox

Meeting Of Elites

The Sirians gather to discuss the assumed reality and the transition from a simulated reality into Lamina

“We are well aware that the software will assume us and create fakes to erode trust. However we have a copy of the software and we will organize a strategy based on its findings.”

Baileyi

WBSCR17

Sits within a chromosomal region homologous to the human Williams–Beuren syndrome region

Is structurally intact (no domestication-related deletions)

Has the wild-type sequence configuration

This region also includes nearby genes like GTF2I, which are important for social behavior.

Encodes a glycosyltransferase-like protein

Participates in protein modification (glycosylation)

May influence neural development indirectly

GTF2I

GTF2I stands for General Transcription Factor II-I.
It encodes a multifunctional transcription factor

A DNA-binding transcription factor

A regulator of gene expression

A signal-responsive protein

acts as a regulatory integrator

GTF2I is located in the region on chromosome 7

GTF2I influences expression of genes involved in:

Oxytocin pathways

Dopamine signaling

Stress hormone regulation

Amygdala reactivity

GTF2I protein contains:

Multiple helix–loop–helix–like repeats

Nuclear localization signals

Phosphorylation sites

is heavily regulated by:

Kinases

AMY2B

AMY2B is the gene that codes for pancreatic alpha-amylase

AMY2B encodes an enzyme that:

Hydrolyzes α-1,4 glycosidic bonds in starch

Usually 2 copies of AMY2B (one per chromosome)

MC1R

MC1R is a gene that encodes the melanocortin-1 receptor

MC1R encodes:

A G-protein–coupled receptor (GPCR)

Located on the surface of melanocytes (pigment-producing cells)

Spans the membrane 7 times (7 transmembrane domains)

Melanocytes can produce:

Eumelanin

Pheomelanin

MC1R determines which pathway is activated

Hormone Binding

A signaling molecule (usually α-MSH, alpha-melanocyte stimulating hormone) binds to MC1R.

Step 2: G-Protein Activation

MC1R activates a G-protein inside the cell.

Step 3: cAMP Increase

This raises intracellular cAMP levels.

interacts with:

Agouti signaling protein (ASIP) → blocks MC1R

Tyrosinase (TYR) → pigment enzyme

CBD103 (K locus) → influences melanism

CBD103

a gene that encodes β-defensin 103, a small antimicrobial peptide

corresponds to the K locus, which controls dominant black coloration

KB

kbr

ky

KB allele overrides Agouti signaling

α-MSH activates MC1R → dark pigment

Agouti blocks MC1R → light pigment

With KB mutation:

β-defensin 103 directly activates MC1R

Does not require α-MSH

IGF1

is a gene that encodes Insulin-Like Growth Factor 1

the main downstream mediator of growth hormone effects

binds to the:

IGF1R

Main pathways:

PI3K–AKT pathway → cell survival & growth

MAPK pathway → cell proliferation

SLC6A4

Serotonin Transporter Gene

SLC6A4 stands for Solute Carrier Family 6 Member 4

encodes the serotonin transporter protein (SERT)

The SERT protein:

Has 12 transmembrane domains

Uses sodium (Na⁺) gradients to function

SLC6A4 controls the intensity and duration of serotonin signaling.

SLC6A4 indirectly influences:

Hypothalamic activation → ACTH → Cortisol

Polymorphisms

5-HTTLPR (a promoter region polymorphism)

Short (S) allele → lower transporter expression

Long (L) allele → higher transporter expression

Sinatu

Unique Haplotypes (mtDNA & Y-chromosome)

Distinct mitochondrial DNA (mtDNA) haplotypes

Certain Y-chromosome lineages that are rare

Immune System 

MHC Class II genes

DLA-DRB1

DQA1

DQB1

MHC Class I loci

Coat Color / Pigmentation

Melanocortin 1 receptor

ASIP

Agouti signaling protein

Diet / Metabolism

AMY2B

Lipid metabolism genes:

PPARA

CPT1A

Stress / Behavioral Regulation

WBSCR17 region

HPA axis genes:

NR3C1 (glucocorticoid receptor)

CRHR1

Simmen

High-Altitude Adaptation Genes

Hypoxia response pathways

EPAS1 Also called HIF-2α (Hypoxia-Inducible Factor 2 Alpha)

EGLN1

HIF1A

Cardiovascular & Oxygen Transport Related Genes

VEGFA

NOS2 / NOS3

Immune System Genes

MHC Class I and II genes

DLA-DRB1

Metabolic & Dietary Adaptation Genes

Lipid metabolism

PPARA

CPT1A

Energy regulation

AMPK pathway genes

Neural / Behavioral Genes

SLC6A4 (serotonin transporter)

Glucocorticoid receptor pathway genes

Vul

Lineage-Specific Gene Families

Olfactory receptor (OR) genes

Behavior Genes

SorCS1

GRM3

SLC6A4

DRD2

Coat Color / Morphology Genes

MC1R

ASIP

TYRP1

KIT

Immune & Environmental Adaptation Genes

MHC gene clusters

Zerda

Desert / Heat Adaptation Genes

AQP1 / AQP2 (Aquaporins)

AVPR2

SLC14A2

Thermoregulation & Fat Metabolism

UCP1

PPARA

CPT1A

Morphology (Ears / Skull Adaptation)

BMP family genes 

FGF genes

Kidney & Osmoregulation Pathways

ACE

REN

Part of RAAS (Renin-Angiotensin-Aldosterone System)

Uroc

Arboreal / Locomotion Adaptation

BMP4 / BMP7

FGF2 / FGF8

COL2A1

Sensory & Behavior Genes

SLC6A4

DRD2

GRIN2B

Immune Genes

MHC Class I and II loci

Metabolism / Diet

PPARA / CPT1A

AMY2B

Mitochondrial Genes

Unique haplotypes in mitochondrial genes:

CYTB

ND2, ND4, ND5

Lyrians - Place of Origin

From the constellation Lyra there is what is called The Ring Nebula (M57)

As a star’s outer atmosphere is drifting into space, in the center is a tiny, extremely dense white dwarf

About the size of Earth

The glowing effect happens because ultraviolet radiation from the white dwarf excites the gas

This becomes part of Lamina as the ring becomes an ultraviolet state of existence. It’s not habitable for an extended amount of time, so the solution is to do what needs to be done to experience it in a way that is meaningful and understanding that this ring is not a permanent place to live.

Lyrians - By Name

Panthra - Tiger

Acino - Cheetah

Yagougaru - Jaguar

Leptai - Serval

Pardali - Ocelot

Viverrin - Lion

looking at the genes uniqueness for each species 

Panthra

Stripe Pattern Genes:

Taqpep

Endothelin 3

Kit and Kitlg

Agouti signaling pathway genes

MC1R

ASIP (Agouti signaling protein)

SLC45A2 – pigment transport - White tigers specifically have a mutation

Sensory Adaptations

RHO (Rhodopsin) – low-light vision

Olfactory receptor gene expansions

Immune System Adaptations

MHC (Major Histocompatibility Complex) genes

Pathogen-response genes